Journal
VACCINE
Volume 30, Issue 20, Pages 3090-3096Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.02.063
Keywords
Japanese encephalitis; Japanese encephalitis vaccines; Vaccines; Immunization
Categories
Funding
- Military Vaccine Agency [MILVAX 10-1-111]
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Background:There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB). Methods: Military personnel who received >= 3 doses of JE-MB or were JE vaccine-naive were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-naive participants post-dose 2. Results: Fifty-three previously vaccinated and 70 JE vaccine-naive participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously naive participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191-520) compared to previously naive participants post-dose 2 (GMT 79; 95% CI 54-114). Conclusions: Among military personnel previously vaccinated with >= 3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB. Published by Elsevier Ltd.
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