Journal
VACCINE
Volume 30, Issue 27, Pages 4040-4045Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.04.029
Keywords
Malaria vaccines; Plasmodium falciparum circumsporozoite protein; Heterologous prime-boost; Ad35-CS; BCC-CS; Long-lived plasma cells
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Funding
- European Commission [LSHP-CT-2007-037494]
- European Virtual Institute for Malaria Research (EVIMalaR)
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Background: Sustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines. Heterologous prime-boost approaches with vectors are optimal strategies to improve a broad and prolonged immunogenicity of malaria vaccines. Results: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen. Moreover, the heterologous prime-boost regimen elicits the highest level of LLPC-mediated immune responses. Conclusion: The increased IFN-gamma-producing cell responses induced by the combination of Ad35-CS/BCG-CS and sustained type 1 antibody profile together with high levels of LLPCs may be essential for the development of long-term protective immunity against liver-stage parasites. (C) 2012 Elsevier Ltd. All rights reserved.
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