Journal
VACCINE
Volume 29, Issue 17, Pages 3335-3339Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.08.067
Keywords
Influenza; Pandemic; Vaccine
Categories
Funding
- NIAID [HHSN266200700005C]
- American Lebanese Syrian Associated Charities
- NIH NIHMS [234984]
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Early epidemiologic and serologic studies have suggested pre-existing immunity to the pandemic A (H1N1) 2009 influenza virus (H1N1pdm) may be altering its morbidity and mortality in humans. To determine the role that contemporary seasonal Hi NI virus infection or trivalent inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following challenge with H1N1pdm. Conversely, prior infection with the contemporary seasonal H1N1 strain altered morbidity, but not transmission, of H1N1pdm despite the detection of only minimal levels of cross reactive antibodies. (C) 2010 Elsevier Ltd. All rights reserved,
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