Journal
VACCINE
Volume 29, Issue 3, Pages 535-544Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.10.046
Keywords
Pneumococcal vaccination; Opsonophagocytic activity
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Funding
- U.S. NIAID [R01 AI 52337, N01 AI-30021]
- Australian National Health and Medical Research Council
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Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) with or without 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months, and subsequent re-exposure to a small dose of pneumococcal polysaccharide antigens (mPPS) at 17 months. Fijian infants were randomized to receive 0, 1, 2, or 3 PCV-7 doses. Half received PPV-23 at 12 months and all received mPPS at 17 months. OPA was performed on up to 14 serotypes. Three and 2 PCV-7 doses resulted in similar OPA for most PCV-7 serotypes up to 9 months and for half of the serotypes at 12 months. A single dose improved OPA compared with the unvaccinated group. PPV-23 significantly improved OPA for all serotypes tested but in general, was associated with diminished responses following re-challenge. (C) 2010 Elsevier Ltd. All rights reserved.
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