Journal
VACCINE
Volume 29, Issue 44, Pages 7595-7598Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.08.049
Keywords
Pneumococcal conjugate vaccine; Carriage; Colonization; Replacement; Otitis media; Haemophilus influenzae; Moraxella catarrhalis; Infants
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Funding
- GlaxoSmithKline
- Wyeth/Pfizer
- Baxter
- Dutch Ministry of Health
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Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7(CRM197)) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50-60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of nonvaccine serotypes. We investigated in a randomized controlled trial the impact of 2-doses and 2 + 1-doses of PCV7(CRM197) on carriage of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children. Nasopharyngeal swabs were collected at the age of 6 weeks and at 6, 12, 18 and 24 months. We observed high carriage rates up to 68% for S. pneumoniae, 71% for H. influenzae and 68% for M. catarrhalis at the age of 18 months. Reduced dose(CRM197) schedules induced a slight reduction in overall pneumococcal carriage but no increases in the presence of H. influenzae and M. catarrhalis. (C) 2011 Elsevier Ltd. All rights reserved.
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