Journal
VACCINE
Volume 29, Issue 8, Pages 1683-1689Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.12.040
Keywords
Malaria vaccine; Recombinant adenovirus; Capsid display; Immunogenicity
Categories
Funding
- NIAID NIH HHS [R56 AI079132, R01 AI079132-01A1, R01 AI079132, R56 AI079132-01] Funding Source: Medline
- NIGMS NIH HHS [R01 GM085024, R01 GM085024-03] Funding Source: Medline
Ask authors/readers for more resources
Adenovirus particles can be engineered to display exogenous peptides on their surfaces by modification of viral capsid proteins, and particles that display pathogen-derived peptides can induce protective immunity. We constructed viable recombinant adenoviruses that display B-cell epitopes from the Plasmodium falciparum circumsporozoite protein (PfCSP) in the major adenovirus capsid protein, hexon. Recombinants induced high-titer antibodies against CSP when injected intraperitoneally into mice. Serum obtained from immunized mice recognized both recombinant PfCSP protein and P. falciparum sporozoites, and neutralized P. falciparum sporozoites in vitro. Replicating adenovirus vaccines have provided economical protection against adenovirus disease for over three decades. The recombinants described here may provide a path to an affordable malaria vaccine in the developing world. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available