Journal
VACCINE
Volume 29, Issue 18, Pages 3390-3397Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.02.085
Keywords
Inactivated polio vaccine; Sabin; Antigenicity; Immunogenicity
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Funding
- World Health Organization
- Bill and Melinda Gates Foundation
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GMP-batches of Sabin-IPV were characterized for their antigenic and immunogenic properties. Antigenic fingerprints of Sabin-IPV reveal that the D-antigen unit is not a fixed amount of antigen but depends on antibody and assay type. Instead of the D-antigen unit we propose standardization of IPV based on a combination of protein amount for dose and D-antigenicity for quality of the vaccine. Although Sabin-IPV type 2 is less immunogenic than regular wild type IPV type 2, the immunogenicity (virus neutralizing titers) per microgram antigen for Sabin-IPV type 2 is in the same order as for wild type serotypes 1 and 3. The latter observations are in line with data from human trials. This suggests that a higher dose of Sabin-IPV type 2 to compensate for the lower rat immunogenicity may not be necessary. (C) 2011 Elsevier Ltd. All rights reserved.
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