Journal
VACCINE
Volume 29, Issue 29-30, Pages 4829-4838Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.04.070
Keywords
Human enterovirus 71; Inactivated vaccine; Cross-protection
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Funding
- Sinovac Biotech Ltd., Beijing, People's Republic of China
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Human enterovirus 71 (HEV71) has emerged as a major cause of epidemics of hand, foot and mouth disease associated with severe neurological sequelae in the Asia-Pacific region. In this study, a passive protection mouse model was used to evaluate the protective efficacy of formalin-inactivated HEV71 vaccines derived from a Chinese C4 genotype strain. Pregnant mice were immunised using a prime/boost strategy and >= 50 U of vaccine protected five-day-old pups from lethal challenge with a mouse-adapted (B3 genotype) strain of HEV71. Immunised mice developed a neutralising antibody response to both the immunising C4 strain and to the mouse-adapted strain. Mice born to immunised dams showed significantly less myositis and reduced viral loads in tissues. (C) 2011 Elsevier Ltd. All rights reserved.
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