Journal
VACCINE
Volume 29, Issue 25, Pages 4274-4284Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.03.043
Keywords
Tetravalent meningococcal vaccine; Conjugate vaccine; Bactericidal activity; Measles-mumps-rubella-varicella vaccine
Categories
Funding
- GlaxoSmithKline Biologicals
- GSK Biologicals
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Co-administration of meningococcal ACWY-tetanus toxoid conjugate vaccine (ACWY-TT) with MMRV vaccine was investigated in 1000 12-23-month old children randomized (3:3:1:1) to receive co-administered ACWY-TT + MMRV, or a single dose of ACWY-TT. MMRV or MenC-CRM197. Non-inferiority of ACWY-TT to MenC-CRM197 and non-inferiority of ACWY-TT + MMRV to ACWY-TT and MMRV alone, and the immunogenicity of serogroups AWY were demonstrated according to pre-defined criteria. Fever reactions in ACWY + MMRV and MMRV groups were comparable. ACWY-TT can be co-administered with MMRV without affecting immunogenicity or safety profiles of either vaccine. This study has been registered at www.clinicaltrials.gov NCT00474266. (C) 2011 Elsevier Ltd. All rights reserved.
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