4.5 Article

Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad

Journal

VACCINE
Volume 29, Issue 34, Pages 5652-5656

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.06.011

Keywords

Vaccine; Cold chain; Controlled temperature chain (CTC); Vaccine vial monitor (VVM); Polio; Oral polio vaccine (OPV); Campaign; Chad; Africa; Immunization; Immunization logistics

Ask authors/readers for more resources

This study is the first systematic documentation of the potency of monovalent oral polio vaccine type 3 (mOPV3) kept at ambient temperatures during a polio immunization campaign in Chad. During the study test vials were exposed to temperatures of up to 47.1 degrees C, and kept outside of the 2-8 degrees C range for a maximum of 86.9 hours. Post-campaign laboratory testing confirmed that the test vials were still potent, and in conformity with the defined release specifications. Further, the Vaccine Vial Monitors performed as expected, giving an early warning indication of when cumulative exposure to heat reached levels that may have negatively affected the vaccine's potency. This study provides proof-of-concept evidence that certain types of OPV remain potent and thus can be kept, for limited periods of time, as well as administered at ambient temperatures. (C) 2011 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available