Journal
VACCINE
Volume 29, Issue 6, Pages 1145-1149Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.12.017
Keywords
Myocardial infarction; Influenza vaccination; Self-controlled case series design
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Funding
- National Institute for Health Research, United Kingdom [PB-PG-0706-10449]
- National Institute for Health Research [PB-PG-0706-10449] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [PB-PG-0706-10449] Funding Source: National Institutes of Health Research (NIHR)
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Acute myocardial infarction (AMI) peaks in winter months, partly linked to epidemic influenza. This implies that influenza vaccination may prevent some cases of AMI. This study investigated the association between influenza vaccination and AMI using the self-controlled case-series method. We identified 8180 cases of first AMI aged 40 years and over at time of diagnosis. The incidence of AMI was significantly reduced in the 60 days following vaccination (compared with the baseline period), ranging from a reduction of 32% (IRR 0.68; 95% CI 0.60-0.78) at 1-14 days after vaccination, to 18% (IRR 0.82; 95% CI 0.75-0.90) at 29-59 days after vaccination. Reductions in AMI incidence were more pronounced for early seasonal vaccinations before mid-November. (C) 2010 Elsevier Ltd. All rights reserved.
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