Journal
VACCINE
Volume 29, Issue 49, Pages 9246-9255Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.09.110
Keywords
Humoral immunity; Influenza vaccine; Sex difference
Categories
Funding
- NIH [AI079342, AI090344]
- Marjorie Gilbert
- Medtronic SWHR award
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A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naive females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge. (C) 2011 Elsevier Ltd. All rights reserved.
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