Journal
VACCINE
Volume 29, Issue 3, Pages 387-390Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.10.082
Keywords
Influenza vaccine effectiveness; Rapid test; Polymerase chain reaction
Categories
Funding
- Centers for Disease Control and Prevention [1 UO1 CI000192-02, U18IP000183]
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Annual evaluation of influenza vaccine effectiveness (VE) is needed to assess ongoing impact of immunization efforts in the setting of antigenic drift and periodic vaccine reformulation. Optimal methodology for determining VE remains unclear. We compared influenza VE generated from prospective enrollment and rRT-PCR testing (active surveillance group) with VE based on clinician-ordered diagnostic tests (clinical testing group) in a defined population over four seasons. VE was calculated as (1 - adjusted OR) for vaccination in cases vs. test-negative controls. VE based on clinical testing underestimated VE based on active surveillance and testing with rRT-PCR by 5-33% depending on season. (C) 2010 Elsevier Ltd. All rights reserved.
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