Journal
VACCINE
Volume 28, Issue 25, Pages 4192-4203Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.04.008
Keywords
Safety; Immunogenicity; 13-valent pneumococcal conjugate vaccine
Categories
Funding
- Pfizer Inc
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13-valent pneumococcal conjugate vaccine (PCV13) was compared to PCV7 in infants administered 4 doses. For the 7 common serotypes, PCV13- and PCV7-elicited responses showed comparable percent responders achieving 0.35 mu g/mL IgG threshold (exception 6B, 77.5% versus 87.1%, respectively) and OPA titers of 1:8; IgGs were lower than PCV7 but functional responses were generally comparable. For the 6 additional serotypes, PCV13-elicited IgG and functional OPA responses were notably greater than PCV7. The toddler dose boosted immune responses. Vaccines were comparable with regard to safety. PCV13 should be as effective as PCV7 in preventing pneumococcal disease caused by the common serotypes and may provide protection against the additional serotypes. (C) 2010 Elsevier Ltd. All rights reserved.
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