Journal
VACCINE
Volume 28, Issue 31, Pages 4861-4863Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.050
Keywords
Chlamydia; Major outer membrane protein; Adoptive transfer
Categories
Funding
- National Health and Medical Research Council
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Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-gamma response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4(+) T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4(+) T cells into naive mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia. (C) 2010 Elsevier Ltd. All rights reserved.
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