Journal
VACCINE
Volume 28, Issue 31, Pages 5057-5067Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.006
Keywords
Neisseria meningitidis; Vaccine; Vesicles
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Funding
- Military Infectious Disease Research Program Office of USAMRMC, U.S. Army
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A vaccine based on native outer membrane vesicles (NOMV) that has potential to provide safe, broad based protection against group B strains of Neisseria meningitidis has been developed. Three antigenically diverse group B strains of N. meningitidis were chosen and genetically modified to improve safety and expression of desirable antigens. Safety was enhanced by disabling three genes: synX, IpxL1, and IgtA. The vaccine strains were genetically configured to have three sets of antigens each with potential to induce protective antibodies against a wide range of group B strains. Preliminary immunogenicity studies with combined NOMV from the three strains confirmed the capacity of the vaccine to induce a broad based bactericidal antibody response. Analysis of the bactericidal activity indicated that antibodies to the LOS were responsible for a major portion of the bactericidal activity and that these antibodies may enhance the bactericidal activity of anti-protein antibodies. (C) 2010 Elsevier Ltd. All rights reserved.
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