Journal
VACCINE
Volume 28, Issue 31, Pages 5023-5030Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.014
Keywords
Neisseria meningitidis; Serum bactericidal activity; MenB vaccine
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Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. (C) 2010 Elsevier Ltd. All rights reserved.
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