Journal
VACCINE
Volume 28, Issue 45, Pages 7331-7336Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.08.075
Keywords
Influenza vaccine; MF59 adjuvant; Children; Adolescents
Categories
Funding
- Novartis Vaccines
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We reviewed the safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents (aged 6 months-18 years) in an integrated analysis of all pediatric trials evaluating MF59-containing influenza vaccines completed to date (5 trials). In the MF59-adjuvanted group (n = 1181) versus the non-adjuvanted group (n = 545) there was no increase in the incidence of unsolicited adverse events and serious adverse events. As expected, solicited local or systemic reactions occurred more frequently in MF59-adjuvanted subjects; however, a majority of reactions were mild and transient. These data support the safety of MF59-adjuvanted influenza vaccines in the pediatric population. (C) 2010 Elsevier Ltd. All rights reserved.
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