Journal
VACCINE
Volume 28, Issue 30, Pages 4842-4846Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.04.042
Keywords
S. pneumoniae pilus; PCV7; Vaccine- and non-vaccine-types
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Funding
- NIH [R01 AI066013, R01 AI066304, R01 AI48935]
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Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, there has been a significant increase in pilus prevalence, now exceeding rates from the pre-conjugate vaccine era. This increase is primarily due to non-VT strains. These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage. (C) 2010 Elsevier Ltd. All rights reserved.
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