Journal
VACCINE
Volume 28, Issue 32, Pages 5245-5253Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.062
Keywords
Clostridium difficile; Vaccine; Economics; Computer simulation
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Funding
- National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) [1U54GM088491-0109]
- Pennsylvania Department of Health
- Bill and Melinda Gates Foundation
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Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease. (C) 2010 Elsevier Ltd. All rights reserved.
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