Journal
VACCINE
Volume 28, Issue 45, Pages 7319-7330Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.08.074
Keywords
Influenza virus; Foxp3(+) T-regulatory cells; Vaccination; Immune responses
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Funding
- Uniformed Services University of the Health [RO83U-07/09]
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The T-regulatory (T-reg) cells restrict the T-cell functions in various viral infections including influenza infection. However little is known about the effect of T-regs in influenza vaccination. Herein, we found that immunization of BALB/c mice with a prototype of UV-inactivated influenza PR8/A/34 virus vaccine expanded the CD4(+)Foxp3(+) T-reg pool and fostered the development of virus-specific CD4(+)Foxp3(+) T-reg cells. Increasing the size of Foxp3(+) T-reg pool did not alter the primary PR8-specific B-cell response, but it did suppress the primary and memory PR8-specific T helper responses induced by vaccination. In contrast, the vaccination-induced T helper cell response was augmented in the absence of CD4(+)Foxp3(+) T-reg cells. Since CD4 T helper cells contribute to anti-influenza protection, therapeutic quenching of T-reg function prior to vaccination may enhance the efficacy of influenza vaccination. Published by Elsevier Ltd.
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