4.5 Article

Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus

Journal

VACCINE
Volume 28, Issue 5, Pages 1325-1332

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.11.013

Keywords

Glycoprotein G; Alphaherpesvirus; Chemokine-binding protein

Funding

  1. Australian Research Council (ARC)
  2. ARC
  3. Instituto de Salud Carlos III

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Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes severe respiratory disease in poultry. Glycoprotein G (gG) is a virulence factor in ILTV. Recent studies have shown that gG-deficient ILTV is an effective attenuated vaccine however the function of ILTV gG is unknown. This study examined the function and in vivo relevance of ILTV gG. The results showed that ILTV gG binds to chemokines with high affinity and inhibits leukocyte chemotaxis. Specific-pathogen-free (SPF) chickens infected with gG-deficient virus had altered tracheal leukocyte populations and lower serum antibody levels compared with those infected with the parent virus. The findings suggest that the absence of chemokine-binding activity during infection with gG-deficient ILTV results in altered host immune responses. (C) 2009 Elsevier Ltd. All rights reserved.

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