Journal
VACCINE
Volume 28, Issue 3, Pages 759-766Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.10.070
Keywords
Influenza vaccine; Hemagglutinin; Quantification; Biosensor
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Quantification of hemagglutinin (HA) by single-radial immuno diffusion (SRID) is the predominant method to ensure product potency in seasonal influenza vaccines. Here a new method for quantification of influenza virus using biosensor technology is presented The method employs quantification of virus via an inhibition assay format using HA proteins for H1N1, H3N2 and B immobilized on a sensor chip. Initial results showed the assay to have higher sensitivity (detection range 0.5-10 9 mu g/ml), higher precision and significantly lower analysis and hands on time compared with SRID (C) 2009 Elsevier Ltd. All rights reserved.
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