Journal
VACCINE
Volume 28, Issue 47, Pages 7460-7467Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.09.042
Keywords
Case-Control studies; Hospitalization; Humans; Influenza A virus; Influenza A virus, H1N1 subtype; Influenza vaccines; Influenza, Human; Reverse transcriptase polymerase chain reaction; Spain; Vaccines, Inactivated
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We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castellon, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147(44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations. (C) 2010 Elsevier Ltd. All rights reserved.
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