Journal
VACCINE
Volume 28, Issue 47, Pages 7529-7535Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.08.107
Keywords
DNA vaccine; Replicon vector; Immunogenicity
Categories
Funding
- National Natural Science Foundation of China [30901375]
- Beijing Natural Science Foundation [7102125]
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Here, DNA replicon vaccines encoding the Hc domain of botulinum neurotoxin serotype A (AHc) or the receptor binding domain of anthrax protective antigen (PA4) with or without signal sequences were evaluated in mice. Strong antibody and protective responses were elicited only from AHc DNA vaccines with an Ig K signal sequence or tissue plasminogen activator signal sequence. Meanwhile, there were no differences in total antibody responses or isotypes, lymphocyte proliferative responses, cytokine profiles and protective immune responses with the PA4 DNA vaccines with or without a signal sequence. Therefore, use of targeting sequences in designing DNA replicon vaccines depends on the specific antigen. (C) 2010 Elsevier Ltd. All rights reserved.
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