Journal
VACCINE
Volume 28, Issue 40, Pages 6573-6580Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.07.067
Keywords
Phase IIa; Malaria vaccine; Sporozoite; Plasmodium falciparum
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Funding
- Dictagene SA, Epalinges, Switzerland
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The aim of this Phase I/IIa double-blind controlled trial was to test the efficacy of the sporozoite-based malaria vaccine PfCS 282-383 (PfCS102) to protect against Plasmodium falciparum parasitaemia. 16 volunteers were randomized to receive twice 30 mu g of PfCS102 formulated in Montanide ISA 720 or ISA 720 alone (control). Two weeks after 2nd immunization, volunteers were challenged using 5 infected mosquitoes. All vaccinees developed antibodies against PfCS102 versus none control. 8/8 vaccinees and 6/6 controls challenged developed malaria parasitaemia. The duration from infection to onset of patent parasitaemia was similar in both groups (214 h in vaccinees and 216 in controls). PfCS102 is safe and immunogenic but provides no protection against artificial challenge in its current formulation. (c) 2010 Elsevier Ltd. All rights reserved.
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