Journal
VACCINE
Volume 28, Issue 21, Pages 3672-3678Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.03.022
Keywords
HIV; Hepatitis B vaccines; Memory B cells
Categories
Funding
- Pediatric AIDS Clinical Trials Group (PACTG)/International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) [5 U01 AI068632-02]
- National Institutes of Health [R01-AI032391, K24-HD001489, P30-AI042845, U01 HD 040533, U01 HD 040474]
- National Institutes on Drug Abuse
- Mental Health
- Duke Center for AIDS Research [P30 AI064518-04]
- National Center for Research Resources, National Institutes of Health, Department of Health and Human Services
- Children's National Medical Center [M01RR020359]
- University of California at San Francisco [M01RR00083-42]
- Pediatric Clinical Research [M01RR01271]
- Tulane/LSU Clinical Trial Research Center
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Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination 10 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/mlat study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals. (C) 2010 Elsevier Ltd. All rights reserved.
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