Journal
VACCINE
Volume 28, Issue 9, Pages 2080-2087Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.12.040
Keywords
HIV-1; Adjuvant; Apoptosis
Categories
Funding
- Swedish Research Council
- Swedish International Development Cooperation Agency/Department for Research Cooperation (SIDA/SAREC)
- European Commission
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Delivery of DNA encoding foreign antigens into mammalian cells can induce adaptive immune responses. There are currently many DNA-based vaccines in clinical trials against infectious diseases and cancer but there is a lack of adjuvants for improvement of responses to DNA-based vaccines. Here, we show augmented systemic and mucosa-associated B cell responses after immunization with a cocktail of seven different plasmids (3 env, 2 gag, 1 rev, 1 RT) combined with mitogen activated apoptotic syngeneic lymphocytes in mice. In addition we show that apoptotic cells can function as adjuvant for induction of cellular immune responses in a magnitude comparable to the cytokine adjuvant GM-CSF in mice. These data suggest that activated apoptotic lymphocytes can act independent as adjuvants to improve antigen-specific DNA vaccines. (C) 2009 Elsevier Ltd. All rights reserved.
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