Journal
VACCINE
Volume 28, Issue 3, Pages 823-833Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.10.049
Keywords
Newcastle Disease Virus; Recombinant turkey herpesvirus; Chitosan; Vaccination; Immunity
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The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines In this context. maternally immune conventional layer chickens were vaccinated in ovo, with a turkey herpesvirus recombinant expressing the fusion (F) gene of NDV (rHVT-ND) and/or at day-old with an apathogenic enterotropic live ND vaccine co-administrated or not with chitosan by oculonasal route. The induced vaccinal immune responses and conferred protection against a challenge with a circulating NDV velogenic viscerotropic strain were evaluated The innovative rHVT-ND/live ND-chitosan vaccination regimen provided the best protection against mortality and morbidity as well as the strongest reduction of virus shedding that could be related to the higher measured cellular immune response and digestive antibody-mediated immunity (C) 2009 Elsevier Ltd. All rights reserved.
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