Journal
VACCINE
Volume 28, Issue 31, Pages 4961-4969Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.032
Keywords
Systemic autoimmunity; Vaccination; Salmo salar
Categories
Funding
- Norwegian School of Veterinary Science
- Lingalaks AS, Strandebarm, Norway
Ask authors/readers for more resources
The development of systemic autoimmunity may result as an undesired side-effect following vaccination, and this condition was recently shown to occur in farmed salmon (Salmo salar). Several of previously reported side-effects following vaccination of fish should therefore be reviewed in the light of this condition. Here, organs and pathological changes in three separate groups of fish severely affected by vaccination were investigated by different morphological methods (n = 84). Granulomas or microgranulomas were observed at the injection site and in several organs. Mott cells were observed in all tissues examined. Pannus-like changes with lymphocyte infiltrates were observed in spines. In conclusion, the reactions following vaccination were of a systemic nature that may be explained by a pathogenetic mechanism caused by systemic autoimmunity. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available