Journal
VACCINE
Volume 27, Issue 49, Pages 6862-6868Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.011
Keywords
Malaria vaccine candidate; Phase I clinical trial; B-cell ELISPOT
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Malaria is a major public health problem in Sub-Saharan Africa. In highly endemic regions infants, children and pregnant women are mostly affected. An effective malaria vaccine would complement existing malaria control strategies because it can be integrated in existing immunization programs easily. Here we present the results of the first phase la clinical trial of GMZ2 adjuvanted in aluminium hydroxide. GMZ2 is a malaria vaccine candidate, designed upon the rationale to induce immune responses against asexual blood stages of Plasmodium falciparum similar to those encountered in semi-immune individuals. Ten, 30 and 100 mu g of GMZ2 were well tolerated in 30 healthy malaria-naive German volunteers when given three times in monthly intervals. Antigen-specific antibodies as well as memory B-cells were induced and detectable throughout the one year follow-up of the study. We conclude that GMZ2 is a safe and immunogenic malaria vaccine candidate suitable for further clinical development. (C) 2009 Elsevier Ltd. All rights reserved.
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