Journal
VACCINE
Volume 27, Issue 25-26, Pages 3276-3280Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.01.062
Keywords
S. aureus; Antigen; Vaccine
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There is a clear unmet medical need for a vaccine that would prevent infections from Staphylococcus aureus (S. aureus). To validate antigens as potential vaccine targets it has to be demonstrated that the antigens are expressed in vivo. Using murine bacteremia and wound infection models, we demonstrate that the expression of clumping factor A (CIfA) and capsular polysaccharide antigens are heterogeneous and dependent on the challenge strains examined and the in Vivo microenvironment. We also demonstrate opsonophagocitic activity mediated by either antigen is not impeded by the presence of the other antigen. The data presented in this report support a multiantigen approach for the development of a prophylactic S. aureus vaccine to ensure broad coverage against this versatile pathogen. (C) 2009 Elsevier Ltd. All rights reserved.
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