Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

Following primary and booster vaccination with ail 11-valent pneumococcall protein D conjugate vaccine there was a 42 8% (95% Cl: -167 to 71 9, ns) reduction in the carriage of Streptococcus pneumomae vaccine serotypes and a 42 6% (95% Cl 1 3-66 6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques When PCR and immunoblot assays were used to further improve specificity of non-typeable It. influenzae strain identification. carriage of 14 influenzae was still reduced with 38 6% (95% CI -6.3 to 64 6. ns) Reduction of acute otitis media (AOM) episodes preceded the impact on carriage These data provide further support of the functional role of the protein D immunity (C) 2009 Published by Elsevier Ltd