Journal
VACCINE
Volume 27, Issue 2, Pages 270-279Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.10.053
Keywords
Tuberculosis; Memory; CD8(+) T-cells
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Funding
- Edward Jenner Institute
- Biotechnology and Biological Sciences Research Council [02/A1/S108455]
- Department for the Environment, Food and Rural Affairs [SE3027]
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Tuberculosis (TB) remains a worldwide leading cause of death among infectious diseases. Development of safer and more efficacious vaccines requires a basic understanding of the protective mechanisms induced by BCG. Here we show that vaccination of cattle with BCG induces CD8(+)gamma/delta TCR-CD45RO(+) T-cells that can produce IFN-gamma, up-regulate transcription and expression of perforin, lyse BCG-infected monocyte-derived macrophages (MoM phi) and contribute to a reduction in the number of intracellular mycobacteria. We also observed BCG-induced CD8(+) responses in vivo. After infection of cattle with Mycobacterium bovis, CD8(+)gamma/delta TCR-CD45RO(+) cells responded more strongly to M. bovis-infected MoM phi than to BCG-infected MoM phi. These results indicate that the antigen-specific CD8(+) memory response resides in the CD8(+)gamma/delta TCR-CD45RO(+) cell population. (C) 2008 Elsevier Ltd. All rights reserved.
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