Journal
VACCINE
Volume 27, Issue 33, Pages 4537-4542Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.05.045
Keywords
Anthrax; Vaccine; Potency
Categories
Funding
- PAHO
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Complexities of lethal challenge models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA and a lethal toxin neutralization assay (TNA) were used to measure antibody response to Protective Antigen (PA) in mice immunized once with either a commercial or a recombinant PA (rPA) vaccine formulated in-house. Even though ELISA and TNA results showed correlation, ELISA results may not be able to accurately predict TNA results in this single immunization model. Published by Elsevier Ltd.
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