Journal
VACCINE
Volume 27, Issue 46, Pages 6432-6434Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.06.015
Keywords
Human papillomavirus; L2 protein; DNA vaccine; Immunogenicity
Categories
Funding
- Poliomyelitis Research Foundation of South Africa
- NCI [RO1 CA 74397]
- NATIONAL CANCER INSTITUTE [R01CA074397] Funding Source: NIH RePORTER
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The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 12 DNA vaccine or with HPV-16 L2 protein. The L2 DNA vaccine elicited a non-neutralizing antibody response unlike the L2 protein. L2 DNA vaccination suppressed the growth of L2-expressing C3 tumor cells, which is a T cell mediated effect, demonstrating that the lack of non-neutralizing antibody induction by L2 DNA was not caused by lack of T cell immunogenicity of the construct. (C) 2009 Elsevier Ltd. All rights reserved.
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