Journal
VACCINE
Volume 27, Issue 47, Pages 6605-6612Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.08.016
Keywords
HIV-1; Vaccine; Envelope protein
Categories
Funding
- Australian NHMRC [299907, 359233]
- Australian Centre for HIV and Hepatitis Virology Research
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We developed highly expressing clade B and AE DNA and envelope protein (Env) vaccines for evaluation in mice and macaques as DNA prime/protein boost regimens. High levels of Env-specific antibodies were induced in mice, albeit with limited neutralizing activity in vitro. A combined clade B and AE regimen induced high titer Env-specific antibody in two pigtail macaques that neutralized several strains of HIV-1. However, upon mucosal challenge with SHIVSF162P3 no protection from infection was observed. Although the vaccines tested provide a platform for inducing robust humoral immunity, further refinements to broaden coverage against divergent strains and induce mucosal immunity are needed. (C) 2009 Elsevier Ltd. All rights reserved.
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