Journal
VACCINE
Volume 27, Issue 15, Pages 2085-2088Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.02.003
Keywords
Hepatitis C virus; T-cell response; Prime-boost regimen
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Funding
- 863 Hi-Tech Research and Development Program of China [2007AA02Z157, 2007AA02Z455]
- National Natural Science Foundation of China [30571673, 30671961]
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To explore the best prime-boost regimen and evaluate the T-cellular response memory against HCV, we constructed two DNA vaccine candidates (pVRC-CE1E2 and pAAV-CE1E2) and two recombinant viruses (rTTV-E1E2 and rAAV-E1E2) and then assessed the immune response to different prime-boost patterns in BALB/c mice. The rTTV-E1E2 boosted the immune response to HCV DNA vaccine prime significantly, and the inverted terminal repeat sequence harboring DNA construct PAAV-CE1E2 was the best prime agent in this study. Our study provides new information for both the prime-boost regimen and long-term T-cell response for HCV vaccine development. (C) 2009 Elsevier Ltd. All rights reserved.
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