Journal
VACCINE
Volume 27, Issue 40, Pages 5488-5495Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.06.103
Keywords
BCG; Vaccination; Birth; Delayed; Polyfunctional CD4 T cells
Categories
Funding
- NIH [R01-AI065653]
- Thrasher Research Foundation
- South African Department of Health
- Bill and Melinda Gates Foundation
- South African Medical Research Council
- Wellcome Trust
- South African National Research Foundation
Ask authors/readers for more resources
Background: In most tuberculosis (TB) endemic countries, bacillus Calmette-Guerin (BCG) is usually given around birth to prevent severe TB in infants. The neonatal immune system is immature. Our hypothesis was that delaying BCG vaccination from birth to 10 weeks of age would enhance the vaccine-induced immune response. Methods: In a randomized clinical trial, BCG was administered intradermally either at birth (n = 25) or at 10 weeks of age (n = 21). Ten weeks after vaccination, and at 1 year of age, vaccine-specific CD4 and CD8 T cell responses were measured with a whole blood intracellular cytokine assay. Results: Infants who received delayed BCG vaccination demonstrated higher frequencies of BCG-specific CD4 T cells, particularly polyfunctional T cells co-expressing IFN-gamma, TNF-alpha and IL-2, and most strikingly at 1 year of age. Conclusions: Delaying BCG vaccination from birth to 10 weeks of age enhances the quantitative and qualitative BCG-specific T cell response, when measured at 1 year of age. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available