Journal
VACCINE
Volume 27, Issue 44, Pages 6110-6115Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.08.034
Keywords
Hepatitis B vaccine; Dose interval; Perinatal transmission
Categories
Funding
- Ministry of Education
- Ministry of Public Health, Thailand
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This two-stage study (cross-sectional and case-control) assessed the effects of delayed second dose HB vaccination on the risk of developing chronic HBV infection in infants born to chronically HBV infected mothers. 521 infants enrolled received the first vaccination by the end of the day afterbirth, without HBIG. 15 of these infants were chronically HBV infected. In the case-control comparison, controlling for HBeAg in the mother, the risk of an infant becoming chronically infected was 3.74 times (95% CI = 0.97-14.39) higher if the interval between the first and the second doses exceeded 10 weeks. This finding suggests it is important that immunization programs ensure timely second dose vaccination to infants born to mothers with chronic HBV infection. Nevertheless, due to the small sample size, these findings should be verified by larger studies. (C) 2009 Elsevier Ltd. All rights reserved.
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