Journal
VACCINE
Volume 27, Issue 52, Pages 7394-7397Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.023
Keywords
Hemolytic anemia; Hemolysis; Pediatrics; Vaccine safety
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Funding
- Centers for Disease Control and Prevention [200-2002-00732]
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Several case reports have described immune hemolytic anemia (IHA) following vaccination in children. We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. in our population-based cohort of nearly 4.5 million children in the Vaccine Safety Datalink, we identified 55 confirmed cases of new-onset lHA from 1991 through 2000. We found no association between lHA and diphtheria-pertussis-tetanus vaccination (incidence rate ratio (IRR) = 0.65, 95% CI: 0.19-2.24), hepatitis B vaccination (IRR = 1.73, 95% CI: 0.59-5.01), or any vaccination (IRR = 1.04, 95% CI: 0.46-2.32). (C) 2009 Elsevier Ltd. All rights reserved.
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