Journal
VACCINE
Volume 27, Issue 39, Pages 5320-5325Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.06.095
Keywords
Rabies; Lyssavirus; EBLV; ABLV; RFFIT; PCECV
Categories
Funding
- Novartis Vaccines and Diagnostics
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Tissue-culture vaccines like purified chick embryo cell vaccine (PCECV) have been shown to provide protection against classical rabies virus (RABV) via pre-exposure or post-exposure prophylaxis. A cross-neutralization study was conducted using a panel of 100 human sera, to determine, to what extent after vaccination with PCECV protection exists against non-classical bat lyssavirus strains like European bat lyssavirus (EBLV) type 1 and 2 and Australian bat lyssavirus (ABLV). Virus neutralizing antibody (VNA) concentrations against the rabies virus variants CVS-11, ABLV, EBLV-1 and EBLV-2 were determined by using a modified rapid fluorescent focus inhibition test. For ABLV and EBLV-2, the comparison to CVS-11 revealed almost identical results (100% adequate VNA concentrations >= 0.5 IU/mL; correlation coefficient r(2) = 0.69 and 0.77, respectively), while for EBLV-1 more scattering was observed (97% adequate VNA concentrations; r(2) = 0.50). In conclusion, vaccination with PCECV produces adequate VNA concentrations against classical RABV as well as non-classical lyssavirus strains ABLV, EBLV-1, and EBLV-2. (C) 2009 Elsevier Ltd. All rights reserved.
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