4.5 Article

Influenza in older adults: Impact of vaccination of school children

Journal

VACCINE
Volume 27, Issue 13, Pages 1923-1927

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.01.108

Keywords

Influenza; Older adults; Herd immunity

Funding

  1. MedImmune
  2. VTEU [N01 AI25462]
  3. NIH/NCRR [5 K12 RR017697-05,]
  4. NIAID [IK23AI074863-01, K23AI065805]

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The extent to which immunizing school children reduce the burden of influenza in adults is controversial. We enrolled a systematic sample of adults >= 50 years hospitalized with respiratory symptoms in two counties, one with and one without a school-based immunization program. We tested all Subjects for influenza by polymerase chain reaction. Hospitalizations per 1000 adults aged >= 50 years were 1.28 (95% Cl 0.59, 2.04) in the intervention county and 1.53 (95% Cl 0.71, 2.34) in the Control County. These rates did not differ significantly except in the subgroup aged 50-64 years where rates in the intervention county were significantly lower. (C) 2009 Elsevier Ltd. All rights reserved.

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