Journal
VACCINE
Volume 27, Issue 15, Pages 2188-2193Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.12.062
Keywords
IC51; Japanese encephalitis; Vaccination regimen
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The standard administration of the investigational Japanese encephalitis vaccine IC51 is 2 doses of 6 mu g with a 28-day interval. This study investigated the immunogenicity of a single-immunization, high-dose regimen (1 x 12 mu g) compared to the 2-injection, standard regimen to determine the immune response that one, high-close injection can confer. The single, high-dose regimen resulted in about 60% seroconversion rate (SCR) at 10 days after administration, but it did not reach the almost 100% SCR achieved by the 2-dose standard administration at Day 35. The standard regimen conferred essentially 100% seroconversion already 7 days after the second immunization. (C) 2009 Elsevier Ltd. All rights reserved.
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