Journal
VACCINE
Volume 27, Issue 18, Pages 2418-2425Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.01.136
Keywords
Granzyme B; Antibody; Influenza vaccination
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Funding
- National Institutes of Health (NIH), National Institute on Aging [R01 AG20634]
- National Institute of Allergy and Infectious Diseases [R01 A168265]
- NIH, National Center for Research Resources [M01 RR06192]
- University of Connecticut Health Center (UCHC)
- Canadian Institutes of Health Research (CIHR)
- Canadian Network of Vaccine Centers of Excellence (CANVAC)
- Medical Scientist of the Alberta Heritage Foundation for Medical Research (AHFMR)
- Howard Hughes International
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This study Compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p = 0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults. (C) 2009 Elsevier Ltd. All rights reserved.
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