Journal
VACCINE
Volume 27, Issue 7, Pages 1050-1054Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.11.100
Keywords
Influenza vaccines; Adverse reactions; Inactivated influenza vaccine; Live-attenuated influenza vaccine
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Funding
- National institute of Allergy and Infectious Diseases [U01 A1057853]
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Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the Study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects who were vaccinated both years, Declines were demonstrated when comparing year 1 and 2 reaction frequencies in subjects vaccinated both years, and differences were seen when comparing year 2 reaction frequencies in subjects vaccinated both years with those first vaccinated in year 2. Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine. (C) 2008 Elsevier Ltd. All rights reserved.
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