Journal
VACCINE
Volume 26, Issue -, Pages D49-D53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.039
Keywords
Influenza virus; RNA viruses; Antigenic shift; Antigenic drift
Categories
Funding
- NIH Center for Investigating Viral Immunity and Antagonism [1 UC19 A1062623-023]
- NIH Center for Research on Influenza Pathogenesis [HHSN266200700010C]
- NIH [UO1 A1070469, UO1 A11074539, T32 A1007623]
- Ruth L. Kirschstein National Research Service Award
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The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in Viruses able to evade the long-term adaptive immune responses in many hosts. (c) 2008 Elsevier Ltd. All rights reserved.
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