Journal
VACCINE
Volume 26, Issue 51, Pages 6614-6619Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.09.078
Keywords
Influenza vaccine; Intradermal; Microinjection; Immune response; Haemagglutination inhibition
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Funding
- Sanofi Pasteur, Lyon, France
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Influenza vaccines remain largely underused. A promising alternative to Current intramuscular vaccines is a trivalent inactivated influenza vaccine (TIV) delivered using a microinjection system to offer a less invasive and possibly more acceptable vaccination. A phase 11, multicentre, randomised open-label study in 978 healthy adults (18-57 years) evaluated the immunogenicity and safety of intradermal TIV. Subjects received a 0.1 ml injection of intradermal TIV, containing 9 mu g of haemagglutinin (HA) per strain (it = 588) or a conventional 0.5 ml intramuscular vaccine (15 mu g of HA/strain: n = 390). Intradermal,11 TIV induced non-inferior humoral immune responses against all three strains and superior responses against both A strains (H1N1, H3N2) compared with the control. Both vaccines were well tolerated. (C) 2008 Elsevier Ltd. All rights reserved.
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