Journal
VACCINE
Volume 26, Issue 37, Pages 4769-4774Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.005
Keywords
measles campaign evaluation
Categories
Funding
- Ministry of Health
- Regional Health Bureau
- Zonal Health Departments
- Assela Health Centre
- Kebele Administration Offices
- National Ethical Committee of the Ethiopian Science and Technology Commission [RDHE/84-31/2000]
- Coventry Research Ethics Committee, UK
- The Council of Regional State of Oromia Health Bureau [QEFAIO/2-7/1745]
- World Health Organisation Department of Vaccines and Biologicals [V21/181/133]
- BASICS, USA
- British Council (Higher Education LINK)
- Addis Ababa, Ethiopia
Ask authors/readers for more resources
We undertook a study to demonstrate the potential contribution of oral-fluid (OF) antibody prevalence surveys in evaluating measles vaccine campaigns. In Asela town, southern Ethiopia, oral fluids were collected from 1928 children aged 9 months to 5 years attending for campaign immunization in December 1999 and 6 months later, from 745 individuals aged 9 months to 19 years, in the same location. Measles antibody status was determined by microimmune measles specific IgG enzyme immunoassay (EIA). Antibody prevalence was estimated at 48% in children attending for vaccination (pre-campaign), and 85% post-campaign in the comparable age group. The estimated reduction in the susceptible proportion was 75%. In older children the proportion antibody negative post-campaign was 28% in 7-9 year olds, and 13% in 10-14 year olds levels of susceptibility which raise concern over continued measles transmission. This is the first evaluation of a measles vaccine campaign based on oral-fluid seroprevalence surveys and it demonstrates the merit of oral-fluid surveys in informing health authorities about vaccination strategy refinement. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available