Journal
VACCINE
Volume 26, Issue 10, Pages 1303-1313Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.12.037
Keywords
nanoparticle; tumor vaccine; antigen presentation/processing
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Nanotechnology is a fundamental technology for designing and generating innovative carriers for biomacromolecular drugs. Biodegradable poly(- -glutamic acid)-based nanoparticles (gamma-PGA NPs) are excellent vaccine carriers capable of delivering antigenic proteins to antigen -presenting cells (APCs) and eliciting potent immune responses based on antigen -specific cytotoxic T lymphocytes. In mice, subcutaneous immunization with gamma-PGA NPs entrapping ovalbumin (OVA) more effectively inhibited the growth of OVA-transfected tumors than immunization with OVA emulsified using Freund's complete adjuvant. In addition, gamma-PGA NPs did not induce histopathotogic changes after subcutaneous injection or acute toxicity through intravenous injection. Importantly, gamma-PGA NPs efficiently delivered entrapped antigenic (C) 2008 Elsevier Ltd. All rights reserved.
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